Promethazine HCl and Codeine Phosphate Oral Answer needs to be applied with caution in sufferers with intense impairment of renal functionality, and individuals really should be monitored carefully for respiratory melancholy, sedation, and hypotension.
The respiratory despair requires a reduction from the responsiveness with the brain stem respiratory centers to both of those improves in carbon dioxide stress and to electrical stimulation.
Severe hypotension usually responds to your administration of norepinephrine or phenylephrine. EPINEPHRINE Really should not be Made use of, considering that its use within a individual with partial adrenergic blockade might additional decrease the hypertension.
When presented concomitantly with promethazine, the dose of barbiturates must be decreased by at least a single-50 %, and the dose of narcotics must be diminished by just one-quarter to at least one-50 percent. Dosage need to be individualized. Extreme amounts of promethazine HCl relative to the narcotic may possibly lead to restlessness and motor hyperactivity within the individual with pain; these indications normally vanish with sufficient control of the agony.
Promethazine really should be used with warning in sufferers with bone marrow depression. Leukopenia and agranulocytosis are documented, usually when promethazine HCl has been Employed in Affiliation with other identified marrow-poisonous agents.
Codeine was not mutagenic while in the in vitro bacterial reverse mutation assay or clastogenic during the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Improved strain within your head (increased intracranial strain). Keep away from the usage of Promethazine Hydrochloride and Codeine Phosphate Oral Option When you've got a head harm or are advised you have changes within the tissue of your respective Mind (Mind lesions) or greater force with your head.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals below six years of age, because The mixture may lead to fatal respiratory depression in this age populace (see WARNINGS – Box Warning and Use In Pediatric Sufferers).
Promethazine Promethazine codeine syrup HCl and Codeine Phosphate Oral Answer must be made use of with caution in sufferers with bone- marrow despair. Leukopenia and agranulocytosis are actually claimed, ordinarily when promethazine has become used in Affiliation with other known marrow-harmful brokers.
Usually do not stand up or sit up immediately, particularly when you will be an older individual. This lowers the risk of dizzy or fainting spells. Alcoholic beverages may interfere Using the result of the medication. Steer clear of alcoholic beverages.
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Nevertheless, this result will not be consistent and should be offset by an increased amount of cervical dilation, which tends to shorten labor. Monitor neonates subjected to opioids for the duration of labor for signs of extra sedation and respiratory depression.
Narcotic analgesics or cough suppressants, such as codeine, should not be used in asthmatic people (see CONTRAINDICATIONS). Nor must they be Employed in acute febrile sickness linked to productive cough or in Serious respiratory sickness wherever interference with ability to apparent the tracheobronchial tree of secretions might have a deleterious impact on the individual's respiratory perform.
If someone has overdosed and has severe signs and symptoms which include passing out or problems breathing, simply call 911. Usually, contact a poison control center immediately.